Targets Hard-to-Digest Gluten and Casein
ProteaseGL™ is a proprietary blend of acid-resistant, non-animal derived digestive enzymes uniquely formulated to provide substantial dipeptidyl peptidase IV (DPP-IV) and related proteolytic activity targeted at optimizing the healthy breakdown of hard-to-digest gluten and casein peptides found in grain-containing and dairy foods, respectively, helping to relieve occasional intestinal discomfort.*
Gluten found in wheat, barley, rye and other cereal grains as well as casein found in dairy foods is difficult for the body to digest which, if not addressed, can result in serious health issues.
ProteaseGL™ is a powerful combination of proteases and peptidases capable of thoroughly digesting gluten and casein.* Avoiding foods containing grains and dairy may seem like the easiest solution to gluten and casein sensitivities or intolerance. Unfortunately, ingredients derived from grains and dairy are often used for nutritional or processing purposes in other common foods, medications and dietary supplements and may not be clearly identified on the label.[7-9]
How ProteaseGL™ Works
A complex formulation of both endopeptidases and exopeptidases, ProteaseGL™ acts on a broad range of peptide bonds, with particular focus on hard-to-digest proline bonds. Laboratory research indicates the type of enzyme blend found in ProteaseGL™ promotes more complete digestion of dietary gluten and casein.* This unique combination of enzymes begins its digestive action immediately upon arriving in the stomach where it survives gastric acidity, continuing to hydrolyze proline bonds before gluten or casein can damage the intestinal mucosa and stimulate an inflammatory response.* Unless a digestive product contains enzymes capable of cleaving proline bonds, it will only be able to partially breakdown gluten or casein which may, in fact, release more resistant peptides and possibly increase the risk of negative reactions in sensitive individuals. Gluteomorphins and caseomorphins are bioactive peptides formed during incomplete digestion of gluten and casein, respectively, which studies have shown can interact with opioid receptors in the brain.[11-14] Further research indicates these bioactive peptides can adversely affect the central nervous system and abnormal levels have been linked to neurological disorders including ADD/ADHD, autism and schizophrenia.[15-17] More complete digestion of dietary proteins with supplemental enzymes including proline-specific peptidases may be beneficial for these conditions.*
Research Supporting ProteaseGL
A sample of ProteaseGL™ (.0685g) was diluted in pH 4.5 acetate buffer. A portion of this (950µL) was added to a solution (50µL) of purified gliadin substrate. The reaction was allowed to shake in a 37 degree water bath for 45 minutes, as this is the average time food starts to move from the stomach to the intestines. The reaction was then boiled for fifteen minutes to stop the reaction from further degradation and allowed to cool for five minutes. The sample was then run on the VeratoxGliadin R5 ELISA kit and read on a micro-plate reader at 655nm. The percent degradation was determined using a standard curve.
ProteaseGL™ has clinically and scientifically demonstrated the ability to not only break down the most resistant proline regions of the gluten or casein molecule but also to digest the entire gluten or casein protein chain into smaller peptides and amino acids the body can absorb and utilize to maintain health.*
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