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ProteaseCW™ is a proprietary blend of acid-resistant, non-animal derived digestive enzymes uniquely formulated to provide substantial proteolytic activity aimed at breaking down the hard-to-digest casein and whey proteins found in dairy foods and protein supplements.*
Dairy foods and many protein supplements contain casein and/or whey, proteins the body has difficulty digesting that often results in not only a significant loss in nutritional value but also gastrointestinal discomfort and, in some cases, serious immune responses. There are large amounts of protein (primarily casein and whey) in dairy products such as milk, cheese, yogurt, and ice cream as well as in popular protein powders and meal replacement drinks. This dairy protein provides essential amino acids, particularly tryptophan, lysine, cysteine and branched chain amino acids, for use by the body in optimizing health.[1,2] Research has also discovered properly-digested dairy protein produces a wide variety of peptides, some with immune-modulating, antibacterial, antiviral, antihypertensive, apoptosis, opioid, mineral-binding and/or antioxidant bioactivities.[3] The digestibility of dairy protein determines not only the nutritional value of the food or supplement but also the body’s ability to tolerate it.[2,4] Intolerances to casein and/or whey, which are often mistaken for an intolerance to dairy lactose, can cause gastrointestinal distress such as bloating, nausea, abdominal pain, and/or diarrhea and, in some cases, more serious immune responses.[5]
A calibrated mix of endo- and exopeptidases with substantial DPP-IV activity attacks the hard-to-cleave X-Pro bonds in casein’s proline-dense segments. These regions tend to fold and cross-link, making them resistant to gastric, pancreatic, and brush-border enzymes; ProteaseCW™ helps open these structures to yield smaller, more manageable peptides [7–10].*
Whey proteins (β-lactoglobulins, α-lactalbumins) are pepsin-resistant due to compact globular folding and stabilizing disulfide bonds. ProteaseCW’s broad bond-specificity across acidic pH expands cleavage beyond pepsin’s limited sites, improving breakdown of these stubborn fractions in the stomach phase [11–14].*
Because the blend is effective under acidic conditions, hydrolysis begins immediately upon gastric entry and continues before casein/whey contact the intestinal mucosa helping limit exposure to intact, more antigenic fragments that can drive intolerance and immune activation. Early, pre-intestinal cleavage supports comfort and tolerance downstream [5,15–16].*
ProteaseCW™ is purpose-built for dairy proteins (casein and whey) not just lactose so you get more nutrition with fewer intolerance triggers. Its calibrated mix of endo- and exopeptidases with substantial DPP-IV activity cleaves hard-to-digest proline-rich motifs in casein that commonly evade gastric, pancreatic, and brush-border enzymes [7–10]. It also opens pepsin-resistant whey fractions (β-lactoglobulins, α-lactalbumins) whose compact folds and disulfide bonds limit pepsin access [11–12, 2, 13–14]. Because the enzymes are acid-stable, hydrolysis begins immediately in the stomach, reducing intact dairy proteins before they contact the intestinal mucosa—helping limit immune stimulation and intolerance-related discomfort downstream [5,15–16]. Multi-site cleavage across a broad pH range (acid/neutral/alkaline proteases) releases essential amino acids and bioactive peptides, enhancing the usable value of dairy foods and protein supplements [2,4]. The enzymes are highly purified and produced via Non-GMO microbial fermentation with a long history of safe and effective use.*
| Approach | What It Targets | Where It Works | Key Takeaways |
|---|---|---|---|
| ProteaseCW™ | Casein + Whey (Broad Bond Specificity; DPP-IV) | Acidic Gastric pH → Ongoing | Comprehensive Dairy Protein Hydrolysis |
| Lactase-Only | Lactose (sugar), Not Protein | Mainly Intestinal | Helps Lactose Intolerance, Not Casein/Whey |
| Generic Protease | Limited Specificity; Often Neutral pH | Less Active in Stomach Acid | Incomplete Breakdown of Dairy Proteins |
ProteaseCW™ is precisely-formulated to assist the body’s own digestive enzymes in thoroughly breaking down dairy protein (casein and whey), releasing essential amino acids and beneficial bioactive peptides as well as minimizing intolerance to dairy protein. Avoiding dairy foods altogether may seem like an easy solution to the problem. However, casein and/or whey are often used for nutritional or processing purposes in other common foods, medications and dietary supplements and may not be clearly identified on the label.[1,6]*
