Natural Prebioitc + Postbioitc

Protect. Nourish. Thrive.

Apple PrePectin™ is a proprietary blend of Non-GMO apple pectin and apple fiber which, when combined with probiotics in a supplement, helps sustain probiotic viability during and after digestion.*

Get a Quote Why Apple PrePectin™ How it Works
  • Protects + Feeds Probiotics for Real Results*
  • Acid-Stable Gel Boosts Live Culture Survivability*
  • Prebiotic Fermentation → SCFAs (Acetate & Butyrate)*
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The Probiotic Problem

The health benefits of probiotic supplementation are often not realized because many probiotic organisms are destroyed during the digestive process and those that make it to the colon do not have adequate nutrition to survive. Probiotic supplementation is widely accepted by the scientific and medical communities as having a beneficial effect on health and well-being, primarily through its influence on the composition and function of intestinal microbiota and stimulation of the immune system. Extensive research supports the use of probiotic supplements in preventive and therapeutic protocols for many conditions caused by altered microbiota in the intestinal tract such as bowel irregularity, antibiotic-associated diarrhea, enterocolitis and irritable bowel syndrome. Allergies, upper respiratory infections, high blood sugar, high cholesterol and obesity have also been linked to aberrant intestinal microbiota.[1-3] However, in order to realize the health benefits of probiotic supplements, a sufficient number of viable organisms must reach the intestines on a regular basis.[4] Although supplemental probiotic strains naturally exhibit varying degrees of resistance to degradation by stomach acid, pepsin, bile, pancreatic enzymes and peristalsis, most will not survive the digestive process without the help of an effective probiotic delivery system. Those organisms that do reach the colon must then have sufficient nutrients available for proliferation, implantation and metabolic activity. Most probiotic delivery systems do nothing to address this important requirement for probiotic survival.[5,6]*

Stomach Acid
Low pH + Pepsin
70% loss of viability
Bile & Enzymes
Pancreatic Secretions
78% loss of viability
Peristalsis
Mechanical Stress
86% loss of viability

How it Works



Probiotic Delivery System

  • Precision Gel Shield: our apple pectin + fiber ratio forms a liquid-activated matrix that wraps live cultures through the upper GI.*
  • More Survivors, More Results: pectin-paired probiotics show higher intestinal viability vs. unprotected strains.*
  • Acid-Stable by Design: premium pectin gels in stomach acidity to deliver more live cultures where they work.*

The precise ratio of apple pectin to apple fiber in Apple PrePectin™ allows it to form a gel-like matrix when ingested with liquid which surrounds the probiotic organisms, protecting them from destruction in the upper digestive tract.[7] Recent studies have demonstrated probiotic organisms combined with pectin exhibited significantly greater viability in the intestines compared to those that were not.[8] Of the many commercially-available pectins, the type used in Apple PrePectin™ possesses the ideal combination of properties required to protect probiotics in the gastrointestinal tract including the capacity to form stable gels in the acidic conditions of the stomach.[9]*


Prebiotic

  • Supercharge Probiotics: stable prebiotic fuel that helps more live cultures survive and thrive.*
  • SCFA Boost: acetate & butyrate for gut defense and resilient colon cells.*
  • Whole-Body Support: better mineral uptake, toxin binding, healthy cholesterol, and calm inflammation.*

Apple PrePectin™ qualifies as a true prebiotic: its apple pectin/fiber remain stable through digestion, are readily fermented by both new and resident gut microbes, and fuel beneficial bacterial growth. [10,11] This fermentation produces short-chain fatty acids—mainly acetate and butyrate [12]; acetate helps defend against pathogenic Gram-negative bacteria such as E. coli [13], while butyrate supports colonic epithelial function and healthy energy/cholesterol metabolism. [14,15] Pectin can also improve mineral absorption and bind heavy metals and chemical toxins for elimination [16], may slow diffusion of cholesterol micelles to help maintain normal blood cholesterol [9], and can increase anti-inflammatory IL-10 production by the intestinal microflora.[17]*

The Apple PrePectin™ Difference

Compared to other probiotic delivery systems and common prebiotics, the ingredients in Apple PrePectin™ are water-extracted, naturally-occurring and hypoallergenic. Various methods are currently being used to increase the number and viability of probiotics reaching targeted locations in the gastrointestinal tract including microencapsulation, multi-layer coatings, enteric coatings and cell surface engineering. Although these techniques have had some success, they often involve the use of either highly-allergenic natural ingredients or completely synthetic polymers/ solvents in a complicated production process that subjects the probiotics to thermal and osmotic stress.[5,6] Probiotic delivery using Apple PrePectin™ is a simple, gel-forming process within the digestive tract that protects the probiotics without added heat, osmotic changes, synthetic or highly allergenic ingredients. Unlike the common prebiotic FOS (fructooligosaccharides) which is highly processed, the pectin and fiber in Apple PrePectin™ are fruit extracts in their native forms. Pectin was found in a recent study to be significantly more effective than inulin, a prebiotic similar in structure to FOS, at supporting the growth of Lactobacillus acidophilus and Bifidobacterium bifidum in the intestinal tract as well as in protecting these organisms from degradation by gastric and pancreatic secretions.[18]*

Approach Core Mechanism Complexity | Inputs Key Takeaways
Apple PrePectin™ In-Body Gel + Prebiotic Fuel Non-GMO Fruit-Derived | No Harsh Processing Protects & Nourishes Simultaneously
Enteric Coating Physical Barrier Pre-Ingestion Synthetic Polymers/Solvents | Thermal/Osmotic Otress Protection Only | Adds MFG Complexity
FOS/Inulin Prebiotic Fermentation Highly Processed Oligosaccharides Less Protective | Different Fermentation Profile

Why Apple PrePectin™

Apple PrePectin™, when added to a supplement containing “live” probiotics, serves two purposes: as a probiotic delivery system, it protects the organisms from harm in the digestive tract and as a prebiotic, it is used to produce metabolic fuel by new and existing microflora in the intestines. With the many well-documented properties of Apple PrePectin™, it is the best choice for oral probiotic delivery and prebiotic function to help optimize the health benefits of probiotic supplementation.*

  • Dual-Action Protection: Hydrates into an acid-stable gel that buffers pH and shields against stomach acid, pepsin, and bile, delivering more viable organisms to the intestines without synthetic coatings.
  • Prebiotic Fuel: Apple pectin + fiber feed exsiting and new microbes, promoting colonization and steady SCFA (acetate, butyrate) production for a resilient gut environment.
  • Clean & Simple: Water-extracted, Non-GMO, hypoallergenic ingredients form and in-body gel which avoids heat, solvents, and osmotic stress for a label-friendly solution.

References


  1. Fact Sheet for Health Professionals. Probiotics. National Institutes of Health, Office of Dietary Supplements. 2019 June.
  2. Sanders ME et al. An update on the use and investigation of probiotics in health and disease. Gut. 2013; 62:787–796.
  3. Nagpal R. Probiotics, their health benefits and applications for developing healthier foods: a review. FEMS Microbiology Letters. 2012 Sept; 334(1): Pages 1–15.
  4. Aurelia P et al. Probiotics and health: An evidence-based review. Pharmacological Research 63 (2011) 366–376.
  5. Jihyun Kim J, Muhammad N, Jhun BH, Yoo JW. Probiotic delivery systems: a brief overview. Journal of Pharmaceutical Investigation2016; 46(4):377-386.
  6. Govender M et al. A Review of the Advancements in Probiotic Delivery: Conventional vs. Non-conventional Formulations for Intestinal Flora Supplementation. AAPS PharmSciTech. 2014 Feb; 15(1):29–43.
  7. Dafe A, Etemadi H, Dilmaghani A, Mahdavinia GR. Investigation of pectin/starch hydrogel as a carrier for oral delivery of probiotic bacteria. Int J Biol Macromol. 2017 Apr; 97:536-543.
  8. Larsen N, Cahú TB , Isay Saad SM , Blennow A , Jespersen L. The effect of pectins on survival of probiotic Lactobacillus spp. in gastrointestinal juices is related to their structure and physical properties. Food Microbiol. 2018 Sep; 74:11-20.
  9. Sharma BR, Naresh L, Dhuldhoya NC, Merchant SU, Merchant UC. An Overview on Pectins. Times Food Processing Journal, 2006 June-July; 44-51.
  10. Petrova P, Petrov KK. Prebiotic–Probiotic Relationship: The Genetic Fundamentals of Polysaccharides Conversion by Bidobacterium and Lactobacillus Genera. Food Bioconversion 2017. 237-278.
  11. Slavin J. Fiber and Prebiotics: Mechanisms and Health Benefits. Nutrients. 2013 Apr; 5(4): 1417–1435.
  12. Kaczmarczyka MM, Miller MJ, Freunda GG. The health benefits of dietary fiber: Beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer. Metabolism: Clinical and Experimental. 2012 Aug; 61(8): 1058-1066.
  13. Lee YL , Cesario T, Owens J, Shanbrom E, Thrupp LD. Antibacterial activity of citrate and acetate. Nutrition. 2002 Jul-Aug; 18(7-8):665-6.
  14. Waldecker M et al. Histone-deacetylase inhibition and butyrate formation: Fecal slurry incubations with apple pectin and apple juice extracts. Nutrition. 2008 Apr;
    24(4):366-74.
  15. Chen Y, Xu C, Huang R, Song J, Li D, Xia M. Butyrate from pectin fermentation inhibits intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein deficient mice. J Nutr Biochem. 2018 Jun; 56:175-182.
  16. Lara-Espinoza C, Carvajal-Millán E, Balandrán-Quintana R, López-Franco Y, Rascón-ChuPectin A. Pectin-Based Composite Materials: Beyond Food Texture. Molecules. 2018 Apr; 23(4): 942.
  17. Chung WSF et al. Prebiotic potential of pectin and pectic oligosaccharides to promote anti-inflammatory commensal bacteria in the human colon. FEMS Microbiol Ecol. 2017 Nov 1;93(11).
  18. Ho YY, Lin CM, Wu MC.  Evaluation of the prebiotic effects of citrus pectin hydrolysate. Journal of Food and Drug Analysis. 2017 July; 25(3): 550-558.