Proteolytic

Protease

An endopeptidase that catalyze the hydrolysis of peptide bonds within protein molecules, producing shorter peptides and free amino acids. This process reduces complex proteins into their fundamental building blocks, which are necessary for tissue repair, enzyme synthesis, and other metabolic functions. Protease enhances the efficiency of dietary protein breakdown, ensuring more complete digestion and nutrient assimilation.*

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ENZYME CLASSIFICATION

EC NUMBER | CAS NUMBER:
3.4.23.18 | 9025-49-4
ENZYME CLASS:
Hydrolase → Peptidase
ENZYME TYPE:
Endopeptidase
ENZYME SOURCE:
Aspergillus oryzae
Enzyme Applications:
Dietary Supplements, Animal Nutrition, Food & Beverage, Brewing & Distilling, Industrial Processing, and Cleaning

TECHNICAL SPECIFICATIONS

ACTIVITY MEASUREMENT:
HUT (Hemoglobin Unit Tyrosine)
PRIMARY SUBSTRATE:
Dietary proteins
BOND CLEAVED:
Internal peptide bonds
PRIMARY PRODUCTS:
Short peptides, oligopeptides
INACTIVATION:
80°C for 30 minutes | pH ≥ 7 for 10 minutes
FORM:
Powder
SOLUBILITY:
Water-soluble
STORAGE:
Store in a cool, dry environment
SHELF-LIFE:
18 months from MFG date if properly stored.
SAFETY & HANDLING:
Always refer to the included Safety Data Sheet.
Protease
Protease

BIOCHEMICAL ROLE IN DIGESTION

Proteases catalyze endopeptidic cleavage within dietary proteins, fragmenting complex polypeptides into shorter peptides that expose additional cleavage sites. This staged hydrolysis increases substrate accessibility for downstream exopeptidases (e.g., amino- and carboxypeptidases) that complete conversion to absorbable amino acids and di-/tripeptides. By reducing molecular size and unraveling tertiary structure, proteases set the pace for comprehensive proteolysis across the digestive tract, preventing intact proteins from persisting into distal segments.*

NUTRITIONAL RELEVANCE IN SUPPLEMENTATION

Supplemental proteases bolster overall protein processing when endogenous output is limited or dietary protein load is high. By accelerating polypeptide fragmentation, they help improve amino acid availability for tissue repair and metabolism, lessen the likelihood of peptide residues reaching the colon, and support more consistent tolerance of diverse protein sources (meat, legumes, grains). This broad coverage makes protease blends a foundational component of multi-enzyme digestive formulas.*