Proteolytic

pHysioProtease®

pHysioProtease® is a multi-enzyme proteolytic complex with broad substrate specificity, designed to act on proteinaceous materials beyond the digestive tract when absorbed systemically. It hydrolyzes fibrin, extracellular protein deposits, and other non-cellular protein substrates, supporting natural tissue turnover and debris clearance.*

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  • Current lead time is 1-8 weeks from date of order confirmation.

For other forms of enzymes contact us for more information.

ENZYME CLASSIFICATION

EC NUMBER | CAS NUMBER:
3.4.23.18 | 9025-49-4
ENZYME CLASS:
Hydrolase → Peptidase
ENZYME TYPE:
Systemic endopeptidase blend
ENZYME SOURCE:
Aspergillus oryzae
Enzyme Applications:
Dietary Supplements

TECHNICAL SPECIFICATIONS

ACTIVITY MEASUREMENT:
HUT (Hemoglobin Unit Tyrosine)
PRIMARY SUBSTRATE:
Fibrin, circulating immune complexes, denatured proteins
BOND CLEAVED:
Internal peptide bonds
PRIMARY PRODUCTS:
Short peptides, amino acids
INACTIVATION:
80°C for 30 minutes
FORM:
Powder
SOLUBILITY:
Water-soluble
STORAGE:
Store in a cool, dry environment
SHELF-LIFE:
18 months from MFG date if properly stored.
SAFETY & HANDLING:
Always refer to the included Safety Data Sheet.
pHysioProtease®
pHysioProtease®

BIOCHEMICAL ROLE IN SYSTEMIC FUNCTION

pHysioProtease® is a blend of non-animal proteolytic enzymes selected for their ability to remain intact through gastric passage and enter circulation. Once absorbed, they associate with plasma proteins such as α2-macroglobulin, enabling systemic transport while preventing immune activation. In circulation, these enzymes interact with cytokines, immune mediators, and extracellular protein substrates, promoting balanced inflammatory signaling and tissue homeostasis.*

NUTRITIONAL RELEVANCE IN SUPPLEMENTATION

As a systemic enzyme blend, pHysioProtease® is designed to modulate whole-body responses rather than act solely in the gut. Supplementation may help support joint health, tissue recovery, balanced inflammatory pathways, and circulatory function. Its multi-enzyme composition allows for broad substrate coverage, making it a comprehensive choice for systemic proteolytic support in advanced formulations.*