Proteolytic

Nattokinase

A subtilisin-like serine protease that catalyzes the hydrolysis of fibrin by cleaving specific peptide bonds, aiding in the natural breakdown of fibrin-rich complexes present in the circulatory system.*

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ENZYME CLASSIFICATION

EC NUMBER | CAS NUMBER:
3.4.21.62 | 133876-92-3
ENZYME CLASS:
Hydrolase → Serine protease
ENZYME TYPE:
Fibrinolytic protease
ENZYME SOURCE:
Bacillus natto
Enzyme Applications:
Dietary Supplements

TECHNICAL SPECIFICATIONS

ACTIVITY MEASUREMENT:
FU (Fibrinolytic Units)
PRIMARY SUBSTRATE:
Fibrin, fibrinogen, fibrin-like proteins
BOND CLEAVED:
Peptide bonds within fibrin mesh structures
PRIMARY PRODUCTS:
Fibrin degradation peptides
INACTIVATION:
55°C for 15 minutes
FORM:
Powder
SOLUBILITY:
Water-soluble
STORAGE:
Store in a cool, dry environment
SHELF-LIFE:
18 months from MFG date if properly stored.
SAFETY & HANDLING:
Always refer to the included Safety Data Sheet.
Nattokinase
Nattokinase

BIOCHEMICAL ROLE IN SYSTEMIC FUNCTION

Nattokinase specifically targets fibrin, a key protein involved in clot formation, by cleaving peptide bonds that stabilize fibrin polymers. It promotes fibrinolysis through both direct enzymatic degradation and indirect activation of plasmin, the body’s natural fibrinolytic enzyme. This dual activity contributes to maintaining circulatory fluidity and protein balance within vascular tissues.*

NUTRITIONAL RELEVANCE IN SUPPLEMENTATION

In supplementation, nattokinase is primarily valued for cardiovascular support. By assisting in the natural regulation of fibrin turnover, it promotes healthy blood flow and circulatory resilience. Its origin from natto, a traditional Japanese fermented food, also provides a long history of safe dietary exposure. Supplementation is particularly relevant where fibrin balance and vascular health are a nutritional focus.*