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A Major Breakthrough in Enzyme Therapeutics

pHysioProtease® is a unique, proprietary blend of powerful, non-animal derived proteolytic enzymes that has a long history of use in effectively helping to modulate the immune system, manage inflammation, and maintain optimal systemic health.* Research has shown pHysioProtease® delivers up to 52 times more activity in the physiological conditions of the blood and tissue fluid than other protease blends taken between meals for systemic purposes.

The Problem

It is now generally accepted in the healthcare community that an imbalance in the body’s inflammatory response, particularly in the activity of cytokines, can greatly exacerbate existing health problems throughout the body, prolonging healing time which may lead to reoccurrence or chronicity.[1,2]

body system chart

The Solution

pHysioProtease®, either ingested by itself or in combination with synergistic herbs, vitamins, minerals or phytonutrients, has been clinically-proven to encourage a normal response to inflammatory stimuli in all areas of the body.* Studies suggest, in some cases, supplemental proteases can be even more effective than anti-inflammatory or analgesic drugs in relieving the symptoms of inflammation without the many adverse side-effects.[6-10]*

How pHysioProtease® Works

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Absorption & A2M Activation

Inflammation Management

Immune Support

Cardiovascular Maintenance

Why pHysioProtease®

By choosing to use proteases that work best in the blood and tissue fluid, despite the additional cost, pHysioProtease® remains the most effective systemic protease blend available for modulating the inflammatory response and supporting immune and cardiovascular functions.


  1. Kaplin MD LJ. Systemic Inflammatory Response Syndrome.
  2. Alexandraki K. et al. Inflammation process in type 2 diabetes: The role of cytokines. Ann N Y Acad Sci. 2006; 1084:89-117.
  3. Sostres C, Gargallo CJ, Lanas A. Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Res Ther. 2013;15 Suppl 3:S3.
  4. Muhammad ZA, Ahmad T. Therapeutic uses of pineapple-extracted bromelain in surgical care – A review. J Pak Med Assoc. 2017 Jan;67(1):121-125.
  5. Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee: a double-blind prospective randomized study. Clin Rheumatol. 2004;23(5):410-415.
  6. WittenBorg A et al. Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti-inflammatory drugs versus an oral enzyme combination preparation. Arzneimittelforschung. 2000; 50(8):728-38.
  7. Kleine MW, Stauder GM, Beese EW. The intestinal absorption of orally administered hydrolytic enzymes and their effects in the treatment of acute herpes zoster as compared with those of oral acyclovir therapy. Phytomedicine. 1995;2(1):7-15.