Why ProteaseGL™

ProteaseGL™ has clinically and scientifically demonstrated the ability to not only break down the most resistant proline regions of the gluten or casein molecule but also to digest the entire gluten or casein protein chain into smaller peptides and amino acids the body can absorb and utilize to maintain health.* The highly-purified proteolytic enzymes in ProteaseGL™ are concentrated from the fermentation of non-genetically modified microorganisms, primarily Aspergillus species with a long history of safe use. ProteaseGL™ is assayed using the DPP-IV method which directly measures the ability of one of the enzymes in the blend, prolyl dipeptidyl peptidase, to hydrolyze proline bonds.[19] In addition, the HUT assay method is performed on this proprietary blend to provide a general measure of its ability to break down large proteins increasing the accessibility to resistant proline bonds under acidic conditions similar to that found in the stomach where optimal gluten and casein digestion takes place.


  1. Doumas A, Broek P, Affolter M, Monod M. Characterization of the Prolyl Dipeptidyl Peptidase Gene (dppIV) from the Koji Mold Aspergillus oryzae. Appl Environ Microbiol. 1998 Dec; 64(12): 4809–4815.