The Problem

It is now generally accepted in the healthcare community that an imbalance in the body’s inflammatory response, particularly in the activity of cytokines, can greatly exacerbate existing health problems throughout the body, prolonging healing time which may lead to reoccurrence or chronicity.[1,2]

A strong immune defense against harmful agents is vital to maintaining the normal structure and function of all body systems. Inflammation is an integral part of a healthy immune system, occurring when tissue has been damaged by invading microorganisms, traumatic injury, altered metabolism, oxidative stress, environmental irritants or any other physical or chemical insult to the body. The inflammatory process begins when tissue damage stimulates the release of chemical mediators including histamine, prostaglandins, leukotrienes, bradykinin and various cytokines which bring about a number of vascular and cellular changes. These chemical mediators cause blood vessels to dilate increasing blood flow to the area. Local blood vessels also become more permeable, allowing fluid and proteins including fibrin to leak into the tissues to isolate the foreign or harmful substance from other parts of the body. Cytokines attract phagocytes to the area to engulf and destroy the offending agent as well as any dead or damaged cellular material in the first step towards tissue regeneration or repair and the end of the inflammatory process.[3]

If the body incorrectly identifies the cause of tissue damage or a harmful agent cannot effectively eliminate a harmful agent or there is interference in the healing process, pro-inflammatory chemical mediators will dominate and inflammation will persist.[4] Progressive tissue damage caused by even low-grade chronic inflammation can result in further functional impairment.[5] Unless this imbalance is addressed, conventional or alternative treatment methods will have difficulty resolving the initial health concern.

The Solution

pHysioProtease®, either ingested by itself or in combination with synergistic herbs, vitamins, minerals or phytonutrients, has been clinically-proven to encourage a normal response to inflammatory stimuli in all areas of the body.* Studies suggest, in some cases, supplemental proteases can be even more effective than anti-inflammatory or analgesic drugs in relieving the symptoms of inflammation without the many adverse side-effects.[6-10]*


  1. Kaplin MD LJ. Systemic Inflammatory Response Syndrome.
  2. Alexandraki K. et al. Inflammation process in type 2 diabetes: The role of cytokines. Ann N Y Acad Sci. 2006; 1084:89-117.
  3. Guyton AC, Hall JE. Resistance of the body to infection: I. Leukocytes, granulocytes, the monocyte-macrophage system, and inflammation. In: Textbook of Medical Physiology. Philadelphia, Pa; W.B. Saunders Company; 1996:439-442.
  4. Anft M. Understanding Inflammation. Johns Hopkins Health Review. Spring/Summer 2016. Vol 3 Issue 1.
  5. Taddei S. et al. Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 2006; 91(12):5076-82.
  6. Sostres C, Gargallo CJ, Lanas A. Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Res Ther. 2013;15 Suppl 3:S3.
  7. Muhammad ZA, Ahmad T. Therapeutic uses of pineapple-extracted bromelain in surgical care – A review. J Pak Med Assoc. 2017 Jan;67(1):121-125.
  8. Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee: a double-blind prospective randomized study. Clin Rheumatol. 2004;23(5):410-415.
  9. WittenBorg A et al. Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti-inflammatory drugs versus an oral enzyme combination preparation. Arzneimittelforschung. 2000; 50(8):728-38.
  10. Kleine MW, Stauder GM, Beese EW. The intestinal absorption of orally administered hydrolytic enzymes and their effects in the treatment of acute herpes zoster as compared with those of oral acyclovir therapy. Phytomedicine. 1995;2(1):7-15.