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The proteases specifically chosen for inclusion in the pHysioProtease® blend are highly resistant to gastric acidity which allows them, when taken between meals, to pass through the acidity of the stomach unharmed and be absorbed intact from the small intestines into the bloodstream.[11-14] These proteases are immediately attached to circulating alpha-2-macroglobulins to keep the enzymes from stimulating an immune response, which occurs when an unshielded foreign protein enters the blood.[15,16] This protease attachment results in a conformational change in the macroglobulin, increasing its activity and mobility to sites of inflammation throughout the body.[17,18] Research suggests this activation of alpha-2-macroglobulins by the type of proteases found in pHysioProtease® is the mechanism by which these supplemental proteolytic enzymes quickly and effectively modulate the inflammatory cascade.* This patented mechanism for increasing activated alpha-2-macroglobulins in the plasma and interstitial fluids (US patent 6,413,512) emphasizes the importance of using systemic proteases with optimal activity in the physiological conditions of the blood and tissue fluid of the body.
Studies have shown supplemental proteases including those found in pHysioProtease® can have a positive effect on the flow characteristics of blood by supporting normal fibrinolytic activity, red blood cell flexibility and vessel wall integrity.[46-49]* Better blood flow assures adequate oxygen, nutrients and fibroblasts are transported to damaged tissue for use in the healing process.
Alpha-2-macroglobulins activated by protease increase macrophage and other phagocytic activity which helps the body break down and eliminate cellular debris and many harmful agents such as microorganisms, allergens, chemicals and rogue cells. The complement system, an integral component of innate immunity, receives assistance from protease-activated alpha-2-macroglobulins in the degradation of inflammation-causing immune complexes circulating in the blood and those deposited in soft tissues.[34-38] Research further shows these active macroglobulins facilitate the clearance of protein damaged by heat or oxidation preventing an accumulation of abnormal proteins in the body with the potential to form destructive amyloids.[39-41] This cleansing or detoxification of the blood, lymph and tissue fluid is an important way pHysioProtease® can enhance the body’s immune response and quality of life.[42-45] *
Protease-activated alpha-2-macroglobulins bind to pro-inflammatory cytokines including TNF-alpha and IL-1 beta, facilitating their rapid clearance through the liver, as well as to anti-inflammatory cytokines such as TGF-beta, assisting in their stimulation of tissue repair.[21-23] These activated macroglobulins have also been found to help control the presence of other pro-inflammatory mediators, especially kinins and prostaglandins, in damaged tissue which may result in less pain, reduced edema and faster recovery.[7, 24-28] The modulating effect of supplemental proteases like pHysioProtease® on inflammation is further supported by studies showing activated alpha-2-macroglobulins can slow the migration of neutrophils to sites of tissue damage or deterioration as well as enhance the activity of macrophages and natural killer cells.[29-33]*