Proteolytic enzymes, including bromelain, papain and protease, are
enzymes that specifically act on protein. Protease taken with food is
completely dedicated to the digestive process and breaks down dietary
proteins into smaller peptides and amino acids that can be easily
absorbed. When taken on an empty stomach with no food to digest,
protease can be absorbed intact into the bloodstream where it appears
to help restore and maintain healthy blood and body functions.
It is well documented that protease acts differently in the tissues of
the body than it does in the digestive tract. Both clinical and
laboratory research shows that proteolytic enzymes taken on an empty
stomach can have a beneficial effect on the immune system and
inflammatory processes. In addition, the amount of protease needed for
systemic activity is often much greater than that needed for digestion.
Yet most systemic protease products on the market contain the same
protease blend found in digestive products. Laboratory analyses have
also found that certain protease exhibits considerably greater activity
in the blood than other protease.
| The significance of alpha-2-macroglobulins
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These macroproteins exist in large numbers
in the presence of inflammation. They help deliver cytokines,
macrophages and fibroblasts to the site of inflammation, so they can
begin the work of reparing damaged tissue.
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Once in the blood stream, specific protease binds to
alpha-2-macroglobulins, causing them to shift to their activated form,
which increases their mobility. This recently patented mechanism for
increasing activated alpha-2-macroglobulin in the blood and
extravascular tissue (US patent 6,413,512) emphasizes the importance of
using systemic protease products that function in the physiological
conditions of the blood and tissues.
pHysioProtease is a proprietary blend of proteases available
exclusively in select products distributed by Enzymes, Inc. Research
has shown that pHysioProtease has the precise combination of proteases
for optimal activity in the physiological conditions of the blood and
other tissues providing maximum patented systemic action. Calcium is
added to help prevent the depletion of intracellular calcium that may
result from the presence of this highly active blend of proteases in
the blood.
A recent study compared pHysioProteases with three commercially
available protease blends recommended for systemic use. The results
revealed that pHysioProtease provided signficantly more systemic enzyme
activity per dose.
*pHysio-U is our designation for the proteolytic activity expected in
the tissues. This unit is based on an innovative assay developed to
measure the activity of protease in simulated conditions for the
temperature, pH, substrates and buffering mechanisms of the blood. The
FCC HUT designation is an indicator of the proteolytic activity in the
conditions of the digestive tract, not the body tissues.
| The statements in this site have not been
evaluated by the Food and Drug Administration. These products are not
intended to diagnose, treat, mitigate, cure or prevent any disease.
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Knowledge Base 
