
ProSol™ (100% vegetarian), our most comprehensive line of digestive and systemic enzyme supplements, includes formulations of microbial enzymes, which have shown to be clinically effective for nearly a decade. There are more than 30 supplements available in the ProSol line, offering support for inflammatory conditions or digestive concerns such as gluten sensitivity or protein malabsorption. ProSol products allow practitioners to focus their therapy based on a patient’s individual needs.
Advanced Formula™ (100% vegetarian) products contain the highest-potency enzymes, herbal extracts and natural-source vitamins and minerals. A 2004 study, published in Plastic and Reconstructive Surgery, determined Advanced Formula InflammEnz™ to be highly effective in reducing inflammation and accelerating soft tissue healing time.
NESS,™: The first professional-strength line of enzyme supplements, NESS was introduced in 1985. Dr. Edward Howell MD, the pioneering founder of vegetarian enzyme therapy, created the NESS line based on more than 50 years of research. Dr. Howell’s book, Enzyme Nutrition, brought about new awareness of the power enzymes have in attaining both digestive and systemic balance.
Joint Care Plus™ is a highly effective combination of NEM Eggshell Membrane, which is rich in a chondroitin sulfate, hyaluronic acid and collagen matrix, and Serratiopeptidase, a potent anti-inflammatory enzyme. An open-label clinical trial on NEM Eggshell Membrane revealed a 72% reduction in pain after just seven days.
A diet rich in protein, carbohydrates, fat, fiber, vitamins and minerals is essential for pet health. Unfortunately, most commercial pet foods are highly processed, and therefore they lack the food enzymes that are essential for digestive health and nutrient absorption. The VET·ZIMES™ product line included five concentrated plant-based enzymes formulas for cats and dogs designed to relieve digestive disturbances, malabsorption, skin problems and urinary tract disorders, among other difficulties available only through licensed veterinarians.
Genuine N·Zimes are the original enzyme supplements introduced by Dr. Edward Howell in 1932. Distributed exclusively by Enzymes, Inc., Genuine N·Zimes are available as capsules or powders in Original and Extra-Strength formulas.
WellZymes™ is our most comprehensive consumer line of digestive and systemic enzyme supplements and homeopathic remedies. The WellZymes line can provide support for several health conditions, including those linked to digestive disorders and pain-causing inflammation.
Nutri-Essence™ products provide general digestive support, as well as an enzyme blend that enhances the release of nutrients from grains, fruits, vegetables and herbs. The Digest Chewables enzyme supplement is especially popular for children or adults who prefer an alternative to capsules. Each Nutri-Essence product is made from the highest-quality vegetarian enzymes and herbal extracts available.
Proteolytic enzymes, including bromelain, papain and protease, are enzymes that specifically act on protein. Protease taken with food is completely dedicated to the digestive process and breaks down dietary proteins into smaller peptides and amino acids that can be easily absorbed. When taken on an empty stomach with no food to digest, protease can be absorbed intact into the bloodstream where it appears to help restore and maintain healthy blood and body functions.
It is well documented that protease acts differently in the tissues of the body than it does in the digestive tract. Both clinical and laboratory research shows that proteolytic enzymes taken on an empty stomach can have a beneficial effect on the immune system and inflammatory processes. In addition, the amount of protease needed for systemic activity is often much greater than that needed for digestion. Yet most systemic protease products on the market contain the same protease blend found in digestive products. Laboratory analyses have also found that certain protease exhibits considerably greater activity in the blood than other protease.
Once in the bloodstream, specific protease binds to alpha-2-macroglobulins, causing them to shift to their activated form, which increases their mobility. This recently patented mechanism for increasing activated alpha-2-macroglobulin in the blood and extravascular tissue (US patent 6,413,512) emphasizes the importance of using systemic protease products that function in the physiological conditions of the blood and tissues.
The proprietary protease blend pHysioProtease™ is available exclusively in select products distributed by Enzymes, Inc. Research has shown that pHysioProtease™ has the precise combination of proteases for optimal activity in the physiological conditions of the blood and other tissues, providing maximum patented systemic action. Calcium is added to help prevent the depletion of intracellular calcium that may result from the presence of this highly active blend of proteases in the blood.
A recent study compared pHysioProtease™ with three commercially available protease blends recommended for systemic use. The results revealed that pHysioProtease™ provided significantly more systemic enzyme activity per dose.

